Journal
CONCEPTS IN MAGNETIC RESONANCE PART B-MAGNETIC RESONANCE ENGINEERING
Volume 37B, Issue 3, Pages 129-145Publisher
WILEY-HINDAWI
DOI: 10.1002/cmr.b.20164
Keywords
computational fMRI; BOLD simulation; high spatial resolution; voxel subdivision; BOLD signal; magnitude; phase; contrast; gridel
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Funding
- NIBIB NIH HHS [R01 EB006841-01A1S1, R01 EB005846-06, R01 EB020407, R01 EB006841-01A1, R01 EB005846, R01 EB005846-01, R01 EB006841, R01 EB005846-03, R01 EB006841-03, R01 EB005846-04, R01 EB006841-04, R01 EB006841-02, R01 EB005846-02, R01 EB005846-05A1] Funding Source: Medline
- NIMH NIH HHS [RC1 MH089257-01, RC1 MH089257] Funding Source: Medline
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High spatial resolution functional MRI (fMRI) provides a more precise estimate of brain activity than low resolution fMRI. The magnitude and phase parts of the blood-oxygenation-level-dependent (BOLD) signals are impacted differently by changes in the scan resolution. In this article, we report on a numerical simulation to show the impact of spatial resolution upon the complex-valued BOLD signal in terms of magnitude and phase variation. We generate realistic capillary networks in cortex voxels, calculate the BOLD-induced magnetic field disturbance and the complex BOLD signals for the voxel and its subvoxels, and thereby characterize the magnitude and phase behaviors across multiple grid resolutions. Our results show that 1) at higher spatial resolution there is greater spatial variation in the phase of the BOLD signal as compared to its magnitude; 2) the spatial variation of the phase signal monotonically increases with respect to spatial resolution while for the magnitude the spatial variation may reach a maximum at some resolution level; 3) voxels containing large capillaries have higher phase spatial variation than those with smaller capillaries; and 4) the amplitude spatial variation at a resolution level increases with respect to relaxation time whereas the phase variation is generally unaffected. (C) 2010 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 37B: 129-145, 2010
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