Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 93, Issue 10, Pages 1061-1073Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-015-1326-7
Keywords
mTOR; Health; TOR; mTORCI; mTORC2; mTOR inhibitors; Rapamycin; Rapalogs; Disease
Funding
- Swiss National Science Foundation
- NCCR RNA and Disease Grant
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Target of rapamycin (TOR) is a highly conserved protein kinase that plays a key role in mediating cell growth and homeostasis. It is activated by nutrients, growth factors, and cellular energy levels to control a number of anabolic and catabolic processes. It is a validated drug target implicated in a variety of diseases. In this review, we describe the molecular mode of action of TOR in the context of cellular and organismal physiology. We focus on mammalian TOR (mTOR) signaling in cancer and neurological disease and discuss usage of TOR inhibitors in the clinic.
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