Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 93, Issue 3, Pages 279-287Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-015-1256-4
Keywords
Cardiac disease; Mitochondria; Mitophagy; Autophagy; Fission; Fusion; Mitochondrial dynamics; Heart
Funding
- National Institutes of Health (NIH) [HL 52141]
- FAPESP [2012/05765-2]
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The processes that control the number and shape of the mitochondria (mitochondrial dynamics) and the removal of damaged mitochondria (mitophagy) have been the subject of intense research. Recent work indicates that these processes may contribute to the pathology associated with cardiac diseases. This review describes some of the key proteins that regulate these processes and their potential as therapeutic targets for cardiac diseases.
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