Journal
COMPUTERS IN BIOLOGY AND MEDICINE
Volume 42, Issue 3, Pages 298-305Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2011.04.019
Keywords
Causal coupling; Modeling; Baroreflex; Cardiopulmonary interactions; Cardiovascular control; Autonomic nervous system
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Funding
- Telethon [GGP09247]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [PDE CNPq 200717/2008-1]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [PDEE/1228/08-0]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paolo [06/52860-0]
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We propose a multivariate dynamical adjustment (MDA) modeling approach to assess the strength of baroreflex and cardiopulmonary couplings from spontaneous cardiovascular variabilities. Open loop MDA (OLMDA) and closed loop MDA (CLMDA) models were compared. The coupling strength was assessed during progressive sympathetic activation induced by graded head-up tilt. Both OLMDA and CLMDA models suggested that baroreflex coupling progressively increased with tilt table inclination. Only CLMDA model indicated that cardiopulmonary coupling due to the direct link from respiration to heart period gradually decreased with tilt table angles, while that due to the indirect link mediated by systolic arterial pressure progressively increased. (C) 2011 Elsevier Ltd. All rights reserved.
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