Journal
COMPUTERS IN BIOLOGY AND MEDICINE
Volume 41, Issue 12, Pages 1082-1091Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2011.05.006
Keywords
Diffusion tensor magnetic resonance imaging; Tract based spatial statistics; Voxel based morphometry; Fractional anisotropy; Ellipsoidal area ratio; Temporal lobe epilepsy
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Funding
- Iran National Science Foundation (INSF)
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White matter (WM) microstructure can be evaluated by diffusion tensor imaging (DTI). Tract-based spatial statistical (TBSS) analysis provides a means of assessing alterations in WM tracts. In this paper, both voxel-based morphometry (VBM) and TBSS are examined using DTI data of temporal lobe epilepsy (TLE) patients and nonepileptic subjects. In addition to fractional anisotropy (FA), ellipsoidal area ratio (EAR) is used in this study. Significant reductions of FA and EAR are identified by TBSS in the parahippocampal white matter. Because of methodological differences, TBSS detects more localized abnormalities than VBM, while the EAR is more sensitive to WM alteration than FA. (C) 2011 Elsevier Ltd. All rights reserved.
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