Journal
COMPUTERS IN BIOLOGY AND MEDICINE
Volume 39, Issue 3, Pages 286-293Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2009.01.002
Keywords
Biological tissue; Laser irradiation; Bioheat transfer; Dual-phase lagging; Protein denaturation; Thermal damage
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A dual-phase lag (DPL) bioheat conduction model, together with the broad beam irradiation method and the rate process equation, is proposed to investigate thermal damage in laser-irradiated biological tissues. It is shown that the DPL bioheat conduction model could predict significantly different temperature and thermal damage in tissues from the hyperbolic thermal wave and Fourier's heat conduction models. It is also found that the DPL bioheat conduction equations can be reduced to the Fourier heat conduction equations only if both phase lag times of the temperature gradient (tau(T)) and the heat flux (tau(q)) are zero. This is different from the DPL model for pure conduction materials. for which it can be reduced to the Fourier's heat conduction model provided that tau(q) = tau(T). Effects of laser parameters and blood perfusion on the thermal damage simulated in tissues are also studied. The result shows that the overall effects of the blood flow on the thermal response and damage are similar to those of the time delay tau(T). (c) 2009 Elsevier Ltd. All rights reserved.
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