Journal
JOURNAL OF MOLECULAR HISTOLOGY
Volume 46, Issue 4-5, Pages 439-442Publisher
SPRINGER
DOI: 10.1007/s10735-015-9634-3
Keywords
Clofazimine; Brain distribution; MALDIMSI
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Funding
- National Research Foundation, SA
- Aspenpharmacare, SA
- University of Kwa-Zulu-Natal, Durban, SA
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This is the first report of clofazimine (CFZ) penetration and distribution in normal mouse brain. Mice were administered 25 mg/kg CFZ or 100 mg/kg CFZ orally, daily for 2 weeks. Animals were sacrificed and blood and brain tissues were harvested. Liquid chromatography tandem mass spectrometry showed high concentrations of CFZ in homogenized brain, with 100 mg/kg dose having significantly higher concentration than 25 mg/kg. Matrix-assisted laser desorption/ionization spectrometric imaging of brain sections showed widespread tissue distribution of CFZ. Our results show dose dependent localization in brain.
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