Journal
JOURNAL OF MOLECULAR EVOLUTION
Volume 81, Issue 3-4, Pages 69-71Publisher
SPRINGER
DOI: 10.1007/s00239-015-9694-8
Keywords
Origin; Genetic code; Glycine; tRNA; CCA
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [25291082]
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tRNA with a terminal UCCA-3' forms a structure in which the 3'-sequence folds back. The adenine of glycyl-AMP can base-pair with the uridine of the UCCA-3' region, which places the glycine residue in close proximity to the 3'-terminal adenosine of tRNA, possibly enabling the transfer of glycine from glycyl-AMP to tRNA. Thus, the UCCA-3'-containing tRNA (as seen in eubacterial tRNA(Gly)s) would possess an intrinsic property of glycylation by glycyl-AMP. This model provides a new perspective on the origins of the glycine assignment in the genetic code, beyond the frozen accident hypothesis.
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