Journal
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
Volume 114, Issue -, Pages 1-6Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molcatb.2014.12.007
Keywords
Cascade reaction; Tandem reaction; Domino reaction; Biocatalysis; Synthetic efficiency
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The astonishing efficiency with which living organisms build complex molecules from simple starting materials has inspired chemists for centuries. Among the synthetic strategies that nature uses to achieve this efficiency, the combination of several enzymatic transformations in cascading sequences is of outstanding importance. With the rise of biocatalysis, researchers now have the tools at hand to mimic this strategy and develop artificial enzyme cascades of impressive complexity. This editorial review aims to introduce the reader to some key aspects of (chemo)enzymatic cascades, as well as to put the submissions to the present Special Issue into a broader context. (C) 2015 Elsevier B.V. All rights reserved.
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