Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 427, Issue 1, Pages 3-30Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2014.08.010
Keywords
voltage-gated sodium channel; structural biology; channel gating; ion permeation; channel pharmacology
Categories
Funding
- National Institutes of Health [R01-HL080050, R01-DC007664, U54-GM094625]
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Voltage-gated sodium channels (Na(V)s) provide the initial electrical signal that drives action potential generation in many excitable cells of the brain, heart, and nervous system. For more than 60 years, functional studies of Nays have occupied a central place in physiological and biophysical investigation of the molecular basis of excitability. Recently, structural studies of members of a large family of bacterial voltage-gated sodium channels (BacNa(V)s) prevalent in soil, marine, and salt lake environments that bear many of the core features of eukaryotic Nays have reframed ideas for voltage-gated channel function, ion selectivity, and pharmacology. Here, we analyze the recent advances, unanswered questions, and potential of BacNa(V)s as templates for drug development efforts. (C) 2014 The Authors. Published by Elsevier Ltd.
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