Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 427, Issue 23, Pages 3722-3733Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2015.08.008
Keywords
evolution of multicellularity; encystation; sporulation; cyclic nucleotide; dual component signalling
Categories
Funding
- Wellcome Trust [100293/Z/12/Z]
- Biotechnology and Biological Sciences Research Council [BB/K000799/1]
- Wellcome Trust [100293/Z/12/Z] Funding Source: Wellcome Trust
- BBSRC [BB/K000799/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/K000799/1] Funding Source: researchfish
- Wellcome Trust [100293/Z/12/Z] Funding Source: researchfish
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Aggregative multicellularity, resulting in formation of a spore-bearing fruiting body, evolved at least six times independently amongst both eukaryotes and prokaryotes. Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba Dictyostelium discoideum. In this review, we summarise trends in the evolution of cell-type specialisation and behavioural complexity in the four major groups of Dictyostelia. We describe the cell cell communication systems that control the developmental programme of D. discoideum, highlighting the central role of cAMP in the regulation of cell movement and cell differentiation. Comparative genomic studies showed that the proteins involved in cAMP signalling are deeply conserved across Dictyostelia and their unicellular amoebozoan ancestors. Comparative functional analysis revealed that cAMP signalling in D. discoideum originated from a second messenger role in amoebozoan encystation. We highlight some molecular changes in cAMP signalling genes that were responsible for the novel roles of cAMP in multicellular development. (C) 2015 The Authors. Published by Elsevier Ltd.
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