Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 83, Issue -, Pages 142-155Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2015.01.011
Keywords
MicroRNA; Long noncoding RNA; Aging; Cardiovascular disease
Categories
Funding
- Ministero della Salute
- Fondazione Cariplo grant [2013-0887]
- Telethon-Italy [GGP14092]
- NIA-IRP, NIH [AG000393-07]
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Eukaryotic gene expression is tightly regulated transcriptionally and post-transcriptionally by a host of noncoding (nc)RNAs. The best-studied class of short ncRNAs, microRNAs, mainly repress gene expression post-transcriptionally. Long noncoding (Inc)RNAs, which comprise RNAs differing widely in length and function, can regulate gene transcription as well as post-transcriptional mRNA fate. Collectively, ncRNAs affect a broad range of age-related physiologic deteriorations and pathologies, including reduced cardiovascular vigor and age-associated cardiovascular disease. This review presents an update of our understanding of regulatory ncRNAs contributing to cardiovascular health and disease as a function of advancing age. We will discuss (1) regulatory ncRNAs that control aging-associated cardiovascular homeostasis and disease, (2) the concepts, approaches, and methodologies needed to study regulatory ncRNAs in cardiovascular aging and (3) the challenges and opportunities that age-associated regulatory ncRNAs present in cardiovascular physiology and pathology. This article is part of a Special Issue entitled CV Aging. (C) 2015 The Authors. Published by Elsevier Ltd.
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