Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 83, Issue -, Pages 44-54Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2014.12.017
Keywords
Autophagy; Cardiac; Aging; Inflammation; Human studies
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Funding
- NHLBI [P01 11-2730]
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Autophagy, a cellular housekeeping process, is essential to maintain tissue homeostasis, particularly in long-lived cells such as cardiomyocytes. Autophagic activity declines with age and may explain many features of age-related cardiac dysfunction. In this review we summarize the current state of knowledge regarding age-related changes in autophagy in the heart. Recent findings from studies in human hearts are presented, including evidence that the autophagic response is intact in the aged human heart. Impaired autophagic clearance of protein aggregates or deteriorating mitochondria will have multiple consequences including increased arrhythmia risk, decreased contractile function, reduced tolerance to ischemic stress, and increased inflammation; thus autophagy represents a potentially important therapeutic target to mitigate the cardiac consequences of aging. This article is part of a Special Issue entitled CV Aging. (C) 2014 The Authors. Published by Elsevier Ltd.
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