Journal
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
Volume 34, Issue 5, Pages 394-403Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compmedimag.2010.01.003
Keywords
Cell morphodynamics; Organogenesis; Focus plus Context volume rendering; Multidimensional dataset visualization; Time-varying visualization
Funding
- European [NEST 012916, NEST 028892]
- European projects Embryomics [NEST 012916]
- European projects Bioemergence [NEST 028892]
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Laser scanning microscopy provides high-resolution nondestructive in vivo imaging to capture specific structures that have been fluorescently labeled, such as cellular nuclei and membranes, throughout early zebrafish embryogenesis. An increasingly challenging problem biologists must face is how to effectively explore, follow, and study the thousands of cells contained in the resulting time-varying volume data that are large in space, time, and variable domain. Visual data explorations, such as direct volume rendering, have been successfully used for the analysis of volumetric data. However, visualizing large-scale time-varying fields remains a challenging problem. In this paper we present a novel Focus + Context animated volume rendering. The technique is based on the distance map of objects of interest and on a scene graph architecture. We demonstrate that distance map driven volume rendering, implemented in modern graphics hardware, is suited to generate run time and interactive representations such as ghosted rendering and cut-away rendering. The experimental results on zebrafish embryogenesis data demonstrate that the technique is suited to uncover and to analyze biological events, such as organogenesis, contained in time-varying volumetric dataset. (C) 2010 Elsevier Ltd. All rights reserved.
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