Journal
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
Volume 199, Issue 29-32, Pages 1937-1948Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cma.2010.02.001
Keywords
Atomistic modeling; Dissipative particle dynamics; Spectrin model
Funding
- NSF
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL094270] Funding Source: NIH RePORTER
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We present a rigorous procedure to derive coarse-grained red blood cell (RBC) models, which yield accurate mechanical response. Based on a semi-analytic theory the linear and nonlinear elastic properties of healthy and infected RBCs in malaria can be matched with those obtained in optical tweezers stretching experiments. The present analysis predicts correctly the membrane Young's modulus in contrast to about 50% error in predictions by previous models. In addition, we develop a stress-free model which avoids a number of pitfalls of existing RBC models, such as non-smooth or poorly controlled equilibrium shape and dependence of the mechanical properties on the initial triangulation quality. Here we employ dissipative particle dynamics for the implementation but the proposed model is general and suitable for use in many existing continuum and particle-based numerical methods. (C) 2010 Elsevier B.V. All rights reserved.
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