Journal
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
Volume 114, Issue 3, Pages E60-E69Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cmpb.2013.06.013
Keywords
Pitavastatin; Compartmental models; Structural identifiability
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In this paper a review of the application of four different techniques (a version of the similarity transformation approach for autonomous uncontrolled systems, a non-differential input/output observable normal form approach, the characteristic set differential algebra and a recent algebraic input/output relationship approach) to determine the structural identifiability of certain in vitro nonlinear pharmacokinetic models is provided. The Organic Anion Transporting Polypeptide (OATP) substrate, Pitavastatin, is used as a probe on freshly isolated animal and human hepatocytes. Candidate pharmacokinetic non-linear compartmental models have been derived to characterise the uptake process of Pitavastatin. As a prerequisite to parameter estimation, structural identifiability analyses are performed to establish that all unknown parameters can be identified from the experimental observations available. (C) 2013 Published by Elsevier Ireland Ltd.
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