Journal
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
Volume 108, Issue 3, Pages 922-931Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cmpb.2012.05.004
Keywords
Wound healing; Release kinetics; Hybrid wound devices
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This paper presents localized and temporal control of release kinetics over 3-dimensional (3D) hybrid wound devices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D. Non-Uniform Rational B-Splines (NURBS) based surface lofting is applied to generate functionally graded regions. Diffusion-based release kinetics model is developed to predict time-based release of loaded modifiers for functionally graded regions. Multi-chamber single nozzle solid freeform dispensing system is used to fabricate wound devices with controlled dispensing concentration. Spatiotemporal control of biological modifiers thus enables a way to achieve target delivery to improve wound healing. (c) 2012 Published by Elsevier Ireland Ltd.
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