Journal
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
Volume 104, Issue 3, Pages 316-324Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cmpb.2011.05.001
Keywords
Electroretinogram; a-Wave; Photoreceptoral response; Achromatopsia; Wavelet analysis
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Most biomedical signals are non-stationary. The knowledge of their frequency content and temporal distribution is then useful in a clinical context. The wavelet analysis is appropriate to achieve this task. The present paper uses this method to reveal hidden characteristics and anomalies of the human a-wave, an important component of the electroretinogram since it is a measure of the functional integrity of the photoreceptors. We here analyse the time-frequency features of the a-wave both in normal subjects and in patients affected by Achromatopsia, a pathology disturbing the functionality of the cones. The results indicate the presence of two or three stable frequencies that, in the pathological case, shift toward lower values and change their times of occurrence. The present findings are a first step toward a deeper understanding of the features of the a-wave and possible applications to diagnostic procedures in order to recognise incipient photoreceptoral pathologies. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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