Journal
JOURNAL OF MICROENCAPSULATION
Volume 32, Issue 3, Pages 308-316Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/02652048.2015.1017619
Keywords
Insulin; insulin microencapsulation; oral delivery; peptides delivery
Funding
- Secretaria de Investigacion y Posgrado from Instituto Politecnico Nacional, Escuela Nacional de Ciencias Biologicas
- CONACYT (Consejo Nacional de Ciencia y Tecnologia) Mexico
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Microcapsules containing insulin were prepared using a combination of a W/O/W double emulsion and complex coacervation between WPI (used as a hydrophilic emulsifier) and CMC or SA with further spray drying of the microcapsules in order to provide protection in the gastrointestinal tract. The microcapsules prepared exhibited high encapsulation efficiency and showed the typical structure of a double emulsion. After spray drying of these microcapsules, the integrity of the W/O/W double emulsion was maintained and the biological residual activity remained high when using the combination of 180 degrees C inlet air temperature and 70 degrees C outlet air temperature. The microcapsules exhibited low solubility at pH 2 and high solubility at pH 7 so they might protect insulin at acid pH values in the stomach and release it at intestinal pH values. The microcapsules developed in this study seem to be a promising oral delivery vehicle for insulin or other therapeutic proteins.
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