Journal
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
Volume 24, Issue 3, Pages 565-574Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JMEMS.2015.2429675
Keywords
Finger driven; local inflammation treatment; microneedles; personal healthcare device
Categories
Funding
- Singapore National Research Foundation [R-263-000-A27-281]
Ask authors/readers for more resources
Patch-based transdermal drug delivery technology offers a convenient way to administer drugs without the drawbacks of standard hypodermic injections related to issues, such as patient acceptability and injection safety. In this paper, we developed a flexible and disposable microneedle-fluidic-system (MFS), which can achieve finger driven on-chip drug loading and delivery functions by integrating polydimethylsiloxane-based microfluidic dispensing networks, check valves, micropump, and SU-8 microneedles in a patch device. The control of particular loading or delivery volume for drugs is provided in terms of finger pressing to a micropump with a given dimension. The in vitro mechanical testing, penetration testing, and delivery testing prove the device functionalities. The local inflammation phenomenon of rats has been ameliorated with the aid of successful diclofenac deliver by our MFS patch.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available