Journal
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
Volume 25, Issue 6, Pages 946-950Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
DOI: 10.4014/jmb.1412.12023
Keywords
Mycobacterium tuberculosis; tamoxifen; intracellular killing; MDR; XDR
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Funding
- Ministry of Health & Welfare R&D Project, Republic of Korea [HI13C0828]
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Recently, it has become a struggle to treat tuberculosis with the current commercial anti-tuberculosis drugs because of the increasing emergence of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We evaluated here the anti-mycobacterial activity of tamoxifen, known as a synthetic anti-estrogen, against eight drug-sensitive or resistant strains of Mycobacterium tuberculosis (TB), and the active intracellular killing of tamoxifen on TB in macrophages. The results showed that tamoxifen had anti-tuberculosis activity against drug-sensitive strains (MIC, 3.125-6.25 mu g/ml) as well as drug-resistant strains (MIC, 6.25 to 12.5 mu g/ml). In addition, tamoxifen profoundly decreased the number of intracellular TB in macrophages in a dose-dependent manner.
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