Journal
COMPTES RENDUS CHIMIE
Volume 14, Issue 7-8, Pages 745-765Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crci.2011.01.002
Keywords
Green chemistry; Organic electrosynthesis; Reactive intermediates; C-C coupling; Functional group interconversion; Umpolung; Radicals
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In organic electrosynthesis C-C bond formation and functional group interconversion proceed via reactive intermediates that are generated by electron transfer at the anode and cathode. Electron transfer combined with a chemical reaction provides conversions that are not available in non-electrochemical reactions. These are potential selectivity, redox-umpolung, and the substitution of a hydrogen atom for a nucleophile or the addition of two nucleophiles to a double bond in one-pot reactions. Furthermore electrolysis is well suited for oxidation and reduction of functional groups. Electrochemical syntheses need mostly fewer steps, produce less waste, provide a cheaper reagent, require less auxiliaries and allow often an easier scale-up than non-electrochemical syntheses. In addition, they can be conducted at ambient temperature and pressure. All these qualities agree well with the rules of green chemistry. This statement is substantiated with examples of C-C bond formation and functional group interconversion at the anode and cathode. (C) 2011 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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