Journal
COMPTES RENDUS CHIMIE
Volume 11, Issue 11-12, Pages 1306-1317Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crci.2008.01.020
Keywords
Resorcylic acid lactones (RALs); Kinase inhibitors; HSP90; Total synthesis; Combinatorial synthesis; Solid-phase synthesis; Polymer supported reagents
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Funding
- Agence National de la Recherche (ANR)
- ARC
- COST (network D28)
- HFSP
- MENRT
- BDI
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The recent discoveries of potent HSP90 and MAP kinase inhibitors amongst the resorcylic acid lactones (RALs) have revived interest in this family of natural products. Both HSP90 and MAP kinase inhibition hold tremendous therapeutic potential, particularly in the treatment of cancer. Our synthetic efforts towards the RALs and, in particular, selective inhibitors of HSP90 and kinases are reviewed. To cite this article: S. Barluenga et al., C R. Chimie 11 (2008). (C) 2008 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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