Journal
COMPTES RENDUS CHIMIE
Volume 11, Issue 11-12, Pages 1523-1543Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crci.2008.02.006
Keywords
Natural products; Maytansinoids; Total synthesis; Semisynthesis; Mutational biosynthesis; Antibiotics
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Maytansine (1) and its congeners have been isolated from higher plants, mosses and from an Actinomycete, Actinosynnema pretiosum. The ansamitocins P-1 to P-4 (11b-11e) are structurally closely related macrolactam antibiotics which have been obtained from bacterial sources, mainly A. pretiosum. Many of these compounds are antitumor agents of extraordinary potency. Detailed structure-activity relationship (SAR) studies have been hampered by the accessibility of analogues in sufficient amounts. The present review focuses on several synthetic approaches towards the maytansinoids which include total synthesis, semisynthesis and mutational biosynthesis utilising genetically engineered microorganisms. To cite this article: A. Kirschning et al., C R. Chimie 11 (2008). (C) 2008 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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