Journal
COMPTES RENDUS CHIMIE
Volume 11, Issue 11-12, Pages 1318-1335Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crci.2008.06.010
Keywords
Resorcylic acid lactone; Kinase inhibitor; Hypothemycin; LL-Z1640-2; Radicicol A; Macrolactonization; Ring-closing olefin metathesis
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The naturally occurring resorcylic acid lactones LL-Z1640-2 (1), hypothemycin (2), L-783277 (3), radicicol A (4) and, to a somewhat lesser extent, aigialomycin D (5) have recently emerged as new lead structures for kinase inhibition. Total syntheses have now been reported for all of these natural products, most of which are based on macrocyclization through ester bond formation. However, RCM-based approaches have also been described and a variety of strategies have been pursued to obtain the requisite seco acids or dienes, respectively, as precursors for macrocyclization. To cite this article: T Hofmann, K.-H. Altmann, C. R. Chimie 11 (2008). (C) 2008 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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