Journal
COMPTES RENDUS BIOLOGIES
Volume 332, Issue 2-3, Pages 273-282Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crvi.2008.07.026
Keywords
Hemoglobin; Myoglobin; Flavohemoglobin; Leghemoglobin
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The superfamily of globins has emerged some 4000 Myr from a common ancestor, which was among the basic protein components required for life. Globins are present in the three kingdoms of life. From a structure point of view, these molecules are defined by the presence of a characteristic protein fold, rich in alpha-helix, surrounding a heme group. Depending on the species or organs, they may be physiologically active as monomers, tetramers or large size polymers. Their function varies from the classical reversible binding of oxygen for transport and storage to cytoprotection against reactive oxygen species, NO scavenging, signaling in oxygen dependent metabolic pathways, or possibly other specific properties involving ligand or electron transfer. All these aspects are discussed in this review. To cite this article: H. Wajcman et al., C R. Biologies 332 (2009). (C) 2008 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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