Journal
COMPOSITES SCIENCE AND TECHNOLOGY
Volume 71, Issue 16, Pages 1842-1849Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.compscitech.2011.08.015
Keywords
Porosity/Voids; Surface treatments; Casting
Categories
Funding
- Research Committee of the Hong Kong Polytechnic University [RU1A]
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The control of pore size and structure, drug release capacity, and biodegradation of scaffolds is of importance for bone tissue engineering. In this study, a technique combining polymer coagulation, cold compression molding, salt particulate leaching and drug coating method was developed to fabricate poly (ethylene glycol)/dexamethasone coated porous poly-D-L-lactide/nano-hydroxyapatite (PDLLA/nano-HAp) scaffolds. These scaffolds possess homogenous pore networks with high porosity (66-82%) and controllable pore size (200-300 mu m). The compressive moduli and strength of the scaffolds after incorporation of nano-HAp were improved by 50% and 20%, respectively. The surface hydrophilicity of the scaffold was significantly improved by poly (ethylene glycol)/dexamethasone coating and nano-HAp addition, leading to a higher initial drug loading amount. The results showed that the drug release behavior of the scaffolds after 35-day immersion in water could be adjusted by varying the porosity level and by incorporation of 20 wt.% of nano-HAp. (C) 2011 Elsevier Ltd. All rights reserved.
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