Journal
COMPOSITES SCIENCE AND TECHNOLOGY
Volume 70, Issue 13, Pages 1861-1868Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.compscitech.2010.05.030
Keywords
Hybrid composites; Nano particles; Surface treatments; Sol-gel methods; Tissue engineering
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This study reports the synthesis and characterization of hydroxyapatite (HA)/polycaprolactone (PCL) hybrid composite materials synthesized by sol-gel method The fabrication of scaffolds was performed by salt-leaching technique using NaCl as porogen agent In the first step, the physico-chemical characterization of composite material was performed to evaluate the composition and the interaction between the organic/inorganic phases. In the second step, optimized scaffolds were bioactivated on the surface The combined effect of scaffold morphology and surface bioactivity is ideal for bone tissue engineering, supporting bone cells adhesion, proliferation and differentiation. Here, a combined strategy involving biomimetic approach, using a supersaturated Simulated Body Fluid (SBF). and salt-leaching technique has been developed to grow hydroxyapatite in composite scaffolds able to regenerate the natural bone (C) 2010 Elsevier Ltd All rights reserved.
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