Preparation and characterization of hollow Fe3O4/SiO2@PEG-PLA nanoparticles for drug delivery

In this study we present a novel targeted anticancer drug delivery, which was size controlled Fe3O4/SiO2 hollow microspheres (HMS) as magnetic core and poly (ethylene glycol)-poly-(D,L-lactide) (PEG-PLA) surface coating (HMS@PEG-PLA). And investigations were to test a new convenient method, which is one-step precipitation polymerization on HMS, forming magnetic hollow polymer microspheres. The HMS@PEG-PLA which have hollow structure and uniform size were characterized by Transmission Electron Microscopy (TEM). Vibrating Sample Magnetometer (VSM) showed a characteristic of super paramagnetic with saturation magnetization value of about 19.78 emu/g. In vitro cytotoxicity of Fe3O4/SiO2@PEG-PLA (HMS@PEG-PLA) hollow microspheres were of low toxicity, so it can be used as a drug carrier, and cisplatin (CDDP) as the model drug release behavior was researched. The results have exhibited preferable release properties. (C) 2013 Elsevier Ltd. All rights reserved.