Journal
JOURNAL OF MEMBRANE BIOLOGY
Volume 248, Issue 4, Pages 611-640Publisher
SPRINGER
DOI: 10.1007/s00232-015-9802-0
Keywords
Membrane proteins; Lipids; Protein structure; Protein function; Protein dynamics; Membrane-mediated interactions
Funding
- Centre Europeen de Calcul Atomique et Moleculaire (CECAM)
- NSF [CHE-0840513, MCB1052477]
- Marie Curie International Reintegration Award [IRG-26920]
- ARC [DP120103548]
- DE Shaw Anton (NRBSC) [PSCA00061P, NIH RC2GM093307]
- VLSCI [VR0200]
- NCI [dd7]
- ERC [268888]
- Reference Framework (NSRF), National Action Cooperation, under grant entitled Magnetic Nanoparticles for targeted MRI therapy (NANOTHER), [11RYM-1-1799]
- European Regional Development Fund
- national resources
- EC under FP7 through Capacities Research Infrastructure
- Virtual Research Communities [INFRA-2010-1.2.3]
- Combination of Collaborative Project
- Coordination and Support Actions (CP-CSA) [RI-261600]
- NSF from the National Science Foundation [MCB1330728]
- National Institutes of Health [PO1GM55876-14A1]
- EU FP7 [PIOF-GA-2012-329534]
- National Science Foundation [CNS-09-58854]
- Irish Research Council
- Instituto de Salud Carlos III FEDER [CP12/03139]
- GLISTEN European Research Network
- European Research Council (ERC) [268888] Funding Source: European Research Council (ERC)
- Direct For Biological Sciences [1330728] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience [1330728] Funding Source: National Science Foundation
Ask authors/readers for more resources
Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.
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