Journal
JOURNAL OF MEDICINAL FOOD
Volume 18, Issue 7, Pages 753-761Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2014.3247
Keywords
hepatic damage; epigallocatechin-3-O-gallate (EGCG); testicular toxicity; di-(2-ethylhexyl) phthalate (DEHP)
Funding
- National Natural Science Foundation of China [31100499]
- Natural Science Foundation of Zhejiang Province [Y3080255]
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The aim of this study was to examine the effects of epigallocatechin-3-O-gallate (EGCG) on hepatic damage and testicular toxicity in male mice exposed to daily oral administration of di-(2-ethylhexyl) phthalate (DEHP). A mouse model was used to assess the effects of daily intraperitoneal EGCG injection on hepatic and testicular damage. Histological and mitochondrial membrane potential results revealed that EGCG treatment significantly arrested the progression of hepatic damage. EGCG treatment resulted in significant suppression of liver injury (i.e., reduced activities of alanine aminotransferase [ALT] and aspartate aminotransferase [AST]). The development of DEHP-induced hepatic and testicular damage altered the testosterone concentration in mouse serum, which could affect the reproductive ability of male mice. Moreover, EGCG treatment markedly attenuated testes lesions, sperm deformity, and spermatogenic cell apoptosis. At the molecular level, hepatic CYP3A4 expression was substantially reduced by EGCG treatment in mice exposed to DEHP compounds, whereas testicular aromatase expression was increased significantly in testes. Thus, these results demonstrate that EGCG administration may protect against liver damage and reproductive toxicity in males exposed to DEHP.
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