Journal
JOURNAL OF MEDICINAL FOOD
Volume 18, Issue 5, Pages 542-548Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2014.3251
Keywords
bone formation; beta-glycosidase; osteoblast; mineralization; differentiation; Panax ginseng
Funding
- Korea Institute of Planning & Evaluation for Technology in Food, Agriculture, Forestry, & Fisheries (KIPET) [313038-03-1-SB010]
- Next-Generation BioGreen 21 Program (SSAC) [PJ00952903]
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In this study, red ginseng extract (RGE) was converted into high-content minor ginsenosides by fermenting with Bgp1 enzymes at 37 degrees C for 5 days. Compared to the RGE, the minor ginsenoside contents were increased in fermented red ginseng extract (FRGE). Moreover, the amount of minor ginsenosides such as Rh1 (11%) and Rg2 (16%) was slightly augmented, while the level of Rg3 (33%) was significantly increased after bioconversion. Furthermore, we also examined and compared the effect of RGE and FRGE on the differentiation and mineralization of preosteoblastic MC3T3-E1 cells. Similarly, the level of mRNA expression of intracellular alkaline phosphatase (ALP) activity, type-1 collagen (Col-I) was also increased. Based on the comparison, it is clear that the FRGE has improved effects on bone formation and differentiation of preosteoblastic MC3T3-E1 cells.
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