Journal
ACS NANO
Volume 9, Issue 9, Pages 8755-8765Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b01440
Keywords
phospholipid bilayer asymmetry; nano-bio interface; sum-frequency generation; secondary ion mass spectrometry; transbilayer movement; silica/water interfaces
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Funding
- National Science Foundation Centers for Chemical Innovation Program, the Center For Sustainable Nanotechnology [CHE-1240151]
- International Institute for Nanotechnology
- Keck Foundation
- State of Illinois
- Northwestern University
- MRSEC [NSF DMR-1121262]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1240151] Funding Source: National Science Foundation
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Given the projected massive presence of redox-active nanomaterials in the next generation of consumer electronics and electric vehicle batteries, they are likely to eventually come in contact with cell membranes, with biological consequences that are currently not known. Here, we present nonlinear optical studies showing that lithium nickel manganese cobalt oxide nanosheets carrying a negative zeta-potential have no discernible consequences for lipid alignment and interleaflet composition in supported lipid bilayers formed from zwitterionic and negatively charged lipids. In contrast, lithiated and delithiated LiCoO2 nanosheets having positive and neutral zeta-potentials, respectively, alter the compositional asymmetry of the two membrane leaflets, and bilayer asymmetry remains disturbed even after rinsing. The insight that some cobalt oxide nanoformulations induce alterations to the compositional asymmetry in idealized model membranes may represent an important step toward assessing the biological consequences of their predicted widespread use.
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