4.4 Article

Nobiletin Protects Dopaminergic Neurons in the 1-Methyl-4-Phenylpyridinium-Treated Rat Model of Parkinson's Disease

Journal

JOURNAL OF MEDICINAL FOOD
Volume 18, Issue 4, Pages 409-414

Publisher

MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2014.3241

Keywords

neuroprotection; dopaminergic neuron; MPP+; nobiletin; microglia; GDNF

Funding

  1. National Research Foundation of Korea (NRF) grant - Korean government [2012R1A1A1039140]
  2. Daegu Science High School RE grant
  3. National Research Foundation of Korea [2012R1A1A1039140] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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This study investigated the effect of nobiletin, a flavonoid found in citrus fruits, on the degeneration of dopaminergic (DA) neurons in a neurotoxin model of Parkinson's disease (PD). 1-Methyl-4-phenylpyridinium (MPP+) was unilaterally injected into the median forebrain bundle of rat brains (to generate a neurotoxin model of PD) with or without daily intraperitoneal injection of nobiletin. Our results showed that nobiletin treatment at 10 mg/kg bw, but not at 1 or 20 mg/kg bw, significantly protected DA neurons in the substantia nigra (SN) of MPP+-treated rats. In parallel to the neuroprotection, nobiletin treatment at 10 mg/kg inhibited microglial activation and preserved the expression of the glial cell line-derived neurotrophic factor, which is a therapeutic agent against PD, in the SN. These results suggest that the proper supplementation with nobiletin may protect against the neurodegeneration involved in PD.

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