Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 58, Issue 7, Pages 2895-2940Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm501371s
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Funding
- National Institutes of Health [GM53386]
- Purdue University
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The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drugtarget interactions through their carbamate moiety. In this Perspective, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent applications of carbamates in drug design and medicinal chemistry.
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