Journal
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
Volume 36, Issue 4, Pages 353-364Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cimid.2013.03.002
Keywords
M cells; MALT; Lymphoid tissue; Follicle-associated epithelium; Cell marker; Lectins; Immunohistochemistry; Mucosal vaccine; Man; Domestic animals
Categories
Ask authors/readers for more resources
M cells play a pivotal role in the induction of immune responses within the mucosa-associated lymphoid tissues. As such, they are frequently studied for the development of mucosal vaccines. Unfortunately, the lack of a universal M cell marker hampers the progress in this field since researchers need species- and tissue-specific markers in order to isolate, identify or target M cells. Depicting the most appropriate M cell marker for the species and tissue under investigation might, however, be complicated by the numerous publications on this topic, often mentioning both positive and negative results for the tested marker. Therefore, this review gives an overview of the specific M cell markers in man and various domestic and laboratory animals. In addition, current state-of-the-art as regards the use of M cell models and markers in mucosal vaccine development is discussed. (c) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available