Journal
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
Volume 31, Issue 5, Pages 403-418Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cimid.2007.06.006
Keywords
monocytes; toll-like receptor; type IIFN; pro-inflammatory cytokine; BVDV; Th1/Th2
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Funding
- Mississippi Agricultural and Forestry Experiment Station (MAFES) [MIRS-999970]
- College of Veterinary Medicine, CVM-INST Monocyte-dependent cytokine polarization profiles in cytopathic and noncytopathic Bovine Viral Diarrhea Virus infection, Mississippi State University
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We have used noncytopathic (ncp) and cytopathic (cp) Bovine Viral Diarrhea Viruses (BVDV) to determine the expression levels of TLR genes, type I IFN, pro-inflammatory and Th1/Th2 cytokine gene expression in bovine monocytes. In general, both BVDV strains had similar effects. However, we found some significant differences that could be due to biological differences between cp and ncp BVDV strains. TLR3 was significantly up-regulated in I h ncp, but not in cp BVDV- infected monocytes, whereas TLR7 expression dominated in 24 h infection with both BVDV strains. Type I IFN and IL-12 gene expression was also significantly upregulated in I h ncp, but not cp BVDV infection that correlated with the enhanced TLR3 gene expression. Both BVDV biotypes suppressed pro-inflammatory cytokines TNF-alpha, IL-1 beta, and IL-6, co-stimulatory molecules CD80 and CD86, but did not change Th1 type cytokine IL-12 and INF-gamma, gene expression after 24h infection. We hypothesize that BVDV may escape immune responses by altering the expression of TLR 3 and 7 and their signaling pathways. (C) 2007 Elsevier Ltd. All rights reserved.
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