Journal
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
Volume 159, Issue 3, Pages 303-312Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpa.2011.03.022
Keywords
Apolipophorin-III; RNAi; Manganese superoxide dismutase; Antioxidant enzyme; Reactive oxygen species
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Funding
- National Research Foundation of Korea [03-2008-0228]
- RINS
- National Research Foundation of Korea [과C6B2606, 2008-531-C00064] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Apolipophorin-III(apoLp-III), a hemolymph protein that facilitates lipid transport in aqueous media in insects was recently shown to play a role in insect immune activation. Here, we report another novel possible function of apoLp-III in insects. To identify genes affected by apoLp-III expression in larvae, we decreased endogenous apoLp-III mRNA in Hyphantria cunea (Hc) through RNA interference; subsequently, we observed lower levels of antioxidant enzymes, including manganese superoxide dismutase (MnSOD), glutathione S-transferase, and immune proteins. Knockdown of Hc apoLp-III led to decreased MnSOD expression in fat body tissues and elevated superoxide anion levels in Hc fat body cells, suggesting that Hc apoLp-III is involved in the action and/or expression of antioxidant enzymes, especially MnSOD. (C) 2011 Elsevier Inc. All rights reserved.
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