Journal
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
Volume 15, Issue 7, Pages 551-554Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138620712801619122
Keywords
Antiplatelet agents; Meldrum's acid; platelet aggregation inhibitors
Funding
- Consolidation Group Research Grant from the Conselleria de Educacion
- FUNDAYACUCHO (Venezuela)
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We herein document the discovery of 5-arylidene-2,2-dimethyl-1,3-dioxane-4,6-diones as a novel family of platelet aggregation inhibitors. The preliminary optimization study enabled us to establish the most salient features of the structure-activity relationships in this series as well as to identify novel derivatives that are upto 60 times more potent than the hit structure 1 and slightly superior to the reference drug Milrinone.
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