Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 173, Issue -, Pages 312-319Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2018.09.065
Keywords
Drug delivery systems; DPPG; Catechins; Liposome; UV radiation
Funding
- FEDER, through Programa Operacional Factores de Competitividade - COMPETE
- Fundacao para a Ciencia e a Tecnologia-FCT
- FCT-MEC (Portugal) [PEst-OE/FIS/UI0068/2011, UID/FIS/00068/2013]
- FAPESP [2013/14262-7]
- CNPq (Brazil)
- RABBIT Doctoral Programme (Portugal) [PD/BD/106036/2015]
- [PTDC/FIS-NAN/0909/2014]
- Fundação para a Ciência e a Tecnologia [PD/BD/106036/2015, PTDC/FIS-NAN/0909/2014] Funding Source: FCT
Ask authors/readers for more resources
Catechin molecules such as epigallocatechin-3-gallate (EGCG) are capable of attenuating the biomolecular damage induced by UV radiation, possibly through molecular mechanisms involving the cell membranes. In this study, we confirmed the protective role of EGCG against UV of 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol) (sodium salt) (DPPG) in liposomes and cast films. The incorporation of EGCG increased the stability of DPPG liposomes as indicated by UV-vis absorption spectra. Using 2D correlation spectroscopy to analyse the spectra, we found that DPPG and EGCG are co-helpers and complement each other against degradation induced by UV. At the molecular level, UV irradiation affects the phosphate and carbonyl groups of DPPG, in addition to triggering the oxidation and opening of the pyrogallol ring of EGCG. Since EGCG can be incorporated into liposomes and is a strong shield against UV radiation, one may envisage its use in anti-ageing and sunscreen creams, and in dermal drug delivery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available