Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 116, Issue -, Pages 72-80Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2013.12.052
Keywords
Surface modification; Scaffolds; Bone regeneration; Mesopore
Funding
- National Basic Research Program of China (973 Program) [2012CB933600]
- National Natural Science Foundation of China [31330028, 31271011]
- National Science and Technology Support Program [2012BAI17B02]
- Program for New Century Excellent Talents in University [NCET-12-0856]
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Scaffolds play a critical role in bone tissue engineering. Composite scaffolds made of biodegradable polymers and bioactive inorganic compounds have demonstrated superior properties in bone defect repair. In this study, highly bioactive, resorbable poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx)-based scaffolds were prepared using combinational 3-dimensional (3D) printing and surface-doping protocol. Structural and morphological characterization of the composite scaffolds demonstrated the homogenous surface-coating of mesoporous bioactive glass (MBG) throughout their porous framework. These hierarchical scaffolds showed bioactivity superior to that of scaffolds made of pure PHBHHx. MBG coating appeared to provide a better environment for human mesenchymal stem cells (hMSCs) attachment, activity, and osteogenic differentiation. Our study indicates that MBG-coated PHBHHx (PHBM) scaffolds may be excellent candidates for use in bone tissue engineering. (C) 2014 Elsevier B.V. All rights reserved.
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