Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 116, Issue -, Pages 49-54Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2013.12.048
Keywords
Drug delivery; Magnetic nanoparticle; Dendrimer; pH-responsive nanocarrier
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A novel magnetic nanocarrier with long spacer length and high colloidal stability has been prepared for effective delivery of doxorubicin (DOX). First, poly(amidoamine) (PAMAM) dendrimer was grown up onto the surface of superparamagnetic iron oxide nanoparticles to increase the loading amount of amine groups. Then, terminal amine groups were functionalized by polyethylene glycol dimethylester to increase the spacer length. Then anticancer drug DOX was covalently attached onto the system by hydrazone bond to forms a pH-sensitive nanocarrier. This system is designed to combine the advantage of magnetic targeting, high drug loading capacity, and controlled release. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
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