Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 123, Issue -, Pages 959-964Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2014.10.050
Keywords
Hydroxyapatite; Polyacrylamide; Composite hydrogel; Mechanical property; Tissue engineering
Funding
- National Science Foundation of China [21274013]
- Fundamental Research Funds for the Central Universities
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Nano-hydroxyapatite/polyacrylamide composite hydrogels were successfully fabricated by physically mixing nano-hydroxyapatite (nHAp) particles into a peroxidized micelles initiated and cross-linked (pMIC) polyacrylamide (PAAm) hydrogel. The nanocomposite hydrogels exhibited excellent mechanical properties. The fracture tensile stresses of the gels were in the range of 0.21-0.86 MPa and the fracture tensile strains were up to 30 mm/mm, and the compressive strengths were up to 35.8 MPa. Meanwhile the introduction of nHAp endowed the composite hydrogels with good cell adhesion properties. This nHAp/PAAm nanocomposite hydrogel is expected to find potential applications in tissue engineering. (C) 2014 Elsevier B.V. All rights reserved.
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