Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 117, Issue -, Pages 29-35Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2014.02.008
Keywords
CT contrast agent; Nanoparticles; Gold; Silver; Antibacterial
Funding
- National Natural Science Foundation of China [21074051, 81371516, 51173077]
- Foundation of National Health and Family Planning Commission of China [W201306]
- Nature Science Foundation of Jiangsu Province [BK2012531]
- AQSIQ Projects [20131K006]
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Au@Ag core-shell nanoparticles (NPs) integrating both antibacterial and X-ray attenuation capabilities were facilely synthesized in aqueous solution. These NPs modified with methoxy-PEG-SH (m-PEG) on the surface rendered them favorable dispersity and stability in water, resulting in enhancement of their blood circulation time. X-ray photoelectron spectroscope (XPS) and high-resolution transmission electron microscope (HRTEM) results confirmed the core-shell structure of m-PEG-Au@Ag NPs. The m-PEG-Au@Ag NPs showed low cytotoxicity and strong X-ray absorption potency in vitro. Further in vivo study showed that as-synthesized NPs offered a pronounced contrast and prolonged their circulation time in the blood stream with negligible toxic effect in vivo. Besides, m-PEG-Au@Ag NPs had significant bacteriostatic effect toward common bacteria like Escherichia coli and Staphylococcus aureus as demonstrated by broth dilution assay. Given their low-cytotoxicity and high CT attenuation efficacy, m-PEG-Au@Ag NPs had a promising potential for use as CT enhancing and antibacterial agents. (C) 2014 Elsevier B.V. All rights reserved.
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