Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 123, Issue -, Pages 339-344Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2014.09.039
Keywords
Liposome; Microgel; Microfluidics; Hydrogel mesh size; Drug releasing
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [2008-0061891]
- Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A103017]
- Korea Institute of Geoscience and Mineral Resources (KIGAM) - Ministry of Knowledge Economy (MEK) of Korea
- R&BD (Research & Business Development) program - Ministry of Trade, Industry and Energy
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This study introduces a drop-based microfluidic approach to physically immobilize liposomes in microgel (liposomes-in-microgel) particles. For this, we generate a uniform liposomes-in-water-in-oil emulsion in a capillary-based microfluidic device. Basically, we have investigated how the flow rate and flow composition affect generation of emulsion precursor drops in micro-channels. Then, the precursor emulsion drops are solidified by photo-polymerization. From characterization of hydrogel mesh sizes, we have figured out that the mesh size of the liposomes-in-microgel particles is bigger than that of bare microgel particles, since liposomes take space in the hydrogel phase. In our further study on drug releasing, we have observed that immobilization of liposomes in the microgel particles can not only remarkably retard drug releasing, but also enables a sustained release, which stems from the enhanced matrix viscosity of the surrounding hydrogel phase. (C) 2014 Elsevier B.V. All rights reserved.
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