4.7 Article

Going viral: Designing bioactive surfaces with bacteriophage

Journal

COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 124, Issue -, Pages 2-16

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2014.05.036

Keywords

Surface functionalization; Virus assembly; Biosensing; Biomaterials; Functional surfaces

Funding

  1. Natural Sciences and Engineering Research Council of Canada (NSERC) strategic network for bioactiVe paper (SENTINEL)
  2. Canada Research Chairs (CRC) program

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Bacteriophage-functionalized bioactive surfaces are functional materials that can be used as antimicrobial surfaces in medical applications (e.g., indwelling medical devices or wound dressings) or as biosensors for bacterial capture and detection. Despite offering immense potential, designing efficient phage-functionalized bioactive surfaces is hampered by a number of challenges. This review offers an overview of the current state of knowledge in this field and presents a critical perspective of the technological promises and challenges. (C) 2014 Elsevier B.V. All rights reserved.

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