Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 117, Issue -, Pages 360-367Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2014.03.010
Keywords
Liposomes; Penetration Enhancer containing Vesicle (PEVs); (Poly)alcohols; Cryo-TEM; DSC; SAXS; Rheology
Funding
- Ministerio de Ciencia e Innovacion, Spain [BIO2011-25039]
- FEDER funds
- Generalitat de Catalunya, Spain [20095GR-760]
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A self-assembled hybrid phospholipid vesicular system containing various penetration enhancers ethanol, Transcutol and propylenglycol - was prepared and characterized. The effects of the different alcohol or polyalcohols structure and their concentration on the features of the assembled vesicles were evaluated using a combination of different techniques, including cryo-transmission electron microscopy, laser light scattering, differential scanning calorimetry, small- and wide-angle X-ray scattering and rheological analysis. These techniques allow explaining the structural rearrangements of the bilayer assembly due to the alcohol or polyalcohol addition. X-ray scattering studies showed that such addition at the highest concentration (20%) allowed structure modification to oligolamellar vesicles and a bilayer transition to interdigitated phase. Rheological studies confirmed the importance of alcohol or polyalcohol in the structuring dispersions probably due to a partial tilting of phosphatidylcholine acyl chains forming interdigitated and interconnected bilayer vesicles. (C) 2014 Elsevier B.V. All rights reserved.
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