Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 113, Issue -, Pages 152-157Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2013.08.043
Keywords
Montmorillonite; Chitosan; Nanocomposites; Silver sulfadiazine; Solid state characterisation
Funding
- Spanish project of the Ministerio de Ciencia e Innovacion (MICINN) [CGL2010-16369]
- Andalusian group [CTS-946]
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Biopolymer chitosan/montmorillonite nanocomposites loaded with silver sulfadiazine for wound healing purposes were prepared via intercalation solution technique. Structure and morphology of loaded nanocomposites were studied and compared with pure components and unloaded nanocomposites. X-ray diffraction, Fourier transformed infrared spectroscopy, high resolution transmission electron microscopy coupled with energy-dispersion X-ray analysis, thermal and elemental analysis were employed for the characterisation. The results confirmed that the drug was effectively loaded in the three-dimensional nanocomposite structures, in which chitosan chains were adsorbed in monolayers into the clay mineral interlayer spaces. (C) 2013 Elsevier B.V. All rights reserved.
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