Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 115, Issue -, Pages 22-28Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2013.11.025
Keywords
Resveratrol; Sulfobutylether-beta-cyclodextrin; FTIR-ATR; Job's plot; Anticancer activity
Funding
- MIUR (Ministerodell'Istruzione, dell'Universita e dellaRicerca) [2009Z8YTYC]
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A resveratrol/sulfobutylether-beta-cyclodextrin inclusion complex was prepared using the freeze-drying method and characterized in solution through UV-vis spectroscopy, solubility phase studies and Job's plot methods. At the solid state it was characterized using the FTIR-ATR technique. Sulfobutylether-beta-cyclodextrin has a high affinity for the drug, and forms an inclusion complex with a 1:1 molar ratio both in solution and as a solid sample. It also has a high stability constant (K-c, 10,114M(-1)). Complexation strongly increases the water solubility of resveratrol (from 0.03 mg/ml to 1.1 mg/ml, at 25 degrees C) and positively influences its in vitro anticancer activity which was observed on a human breast cancer cell line (MCF-7). In solid phase, FTIR-ATR revealed itself as being a useful technique in elucidating the complexation mechanism, which it did by emphasizing the functional groups involved in the activation of non-covalent host-guest interactions. (C) 2013 Elsevier B.V. All rights reserved.
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