Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 111, Issue -, Pages 493-502Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2013.06.031
Keywords
Bacterial cellulose; Biocompatibility; Biomaterials; Polyvinyl alcohol; Platelets; Hemocompatibility
Funding
- FCT [PTDC/EBB-EBI/112170/2009, SFRH/BD/66094/2009]
- COST-Short Term Mission [COST-STSM-TD1003-8978]
- Department of Industry of the Basque Government program ETORTEK
- Spanish Ministry of Science and Innovation [CTQ2009-11245]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/66094/2009, PTDC/EBB-EBI/112170/2009] Funding Source: FCT
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Bacterial cellulose (BC) has been suggested to be a suitable biomaterial for the development of cardiovascular grafts. The combination of BC with polyvinyl alcohol (PVA) results in nanocomposites with improved properties. Surprisingly, there are very few studies on the BC blood interaction. This is the focus of this paper. We present the first thorough assessment of the hemocompatibility of the BC/PVA nanocomposite. Whole blood clotting time, plasma recalcification, Factor XII activation, platelet adhesion and activation, hemolytic index and complement activation are all determined. The platelet activation profiles on BC and BC/PVA surfaces are comprehensively characterized. BC and BC/PVA outperformed ePTFE - used as a point of comparison thus evidencing their suitability for cardiovascular applications. (C) 2013 Elsevier B.V. All rights reserved.
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